Publications shown in the last 10 years. For a full list of publications from PubMed, click here.
2025
Streptomyces venezuelae uses secreted chitinases and a designated ABC transporter to support the competitive saprophytic catabolism of chitin
Authors: van der Meij A, Tyrrell H, Sokolowski DJ, Shepherdson EMF, Elliot MA, Nodwell JR
Reference: PLoS Biology Aug 2025; doi: 10.1371/journal.pbio.3003292
Phosphorylation by the PknB serine/threonine kinase stimulates dimer formation by WalR
Authors: Suppi M, Monk IR, Sharkey LKR, Scott NE, Dweipayan G, Natarajan A, Tan S, Myler K, Pimentel-Elardo SM, Stinear TP, Pidot SJ, Nodwell JR
Reference: bioRxiv Jul 2025; doi: 10.1101/2025.07.12.664526
Differentiating bacteria by their unique surface interaction
Authors: Kotoulas NK, Tan S, Nodwell JR, Goh MC
Reference: PLoS One Jun 2025; doi: 10.1371/journal.pone.0327489
Regulation to function: A computational approach to specialized metabolism
Authors: Nodwell JR
Reference: PLoS Biology Jun 2025; doi: 10.1371/journal.pbio.3003205
Characterizing antimicrobial activity of environmental Streptomyces spp. and oral bacterial fungal isolates from Canis familiaris and Felis catus
Authors: Cowen A, Yiu B, Fallah S, Meyer KJ, Puumala E, Lee Y, Zubyk HL, Robbins N, Nodwell JR, MacAlpine J, Cowen LE.
Reference: mSphere Apr 2025; doi: 10.1128/msphere.00098-25
2024
Phosphatidylethanolamine is a phagocytic ligand implicated in the binding and removal of microbial extracellular vesicles
Authors: Kavianpour A, Meyer KJ, Le T, Marques PE, Nodwell JR, Freeman SA.
Reference: bioRxiv Nov 2024; doi: 10.1101/2024.11.18.624161
Streptomyces extracellular vesicles are a broad and permissive antimicrobial packaging and delivery system
Authors: Meyer KJ, Nodwell JR.
Reference: J. Bacteriol. Feb 2024; doi: 10.1128/jb.00325-23
2023
A contractile injection system is required for developmentally regulated cell death in Streptomyces coelicolor
Authors: Vladimirov M, Zhang RX, Mak S, Nodwell JR, Davidson AR.
Reference: Nat. Commun. Mar 2023; doi: 10.1038/s41467-023-37087-7
PRKN/parkin-mediated mitophagy is induced by the probiotics Saccharomyces boulardii and Lactococcus lactis
Authors: Hawrysh PJ, Gao J, Tan S, Oh A, Nodwell JR, Tompkins T, McQuibban A.
Reference: Autophagy. Jan 2023; doi: 10.1080/15548627.2023.2172873
2022
A defect in cell wall recycling confers antibiotic resistance and sensitivity in Staphylococcus aureus
Authors: Tan S, Cho K, Nodwell JR.
Reference: J. Biol. Chem. Oct 2022; doi: 10.1080/14786419.2019.1698571
High-throughput chemical screen identifies a 2,5-disubstituted pyridine as an inhibitor of Candida albicans Erg11
Authors: Du Bois AC, Xue A, Pham C, Revie NM, Meyer KJ, Yashiroda Y, Boone C, Nodwell JR, Stogios P, Savchenko A, Robbins N, Iyer KR, Cowen LE.
Reference: mSphere. Jun 2022; doi: 10.1080/14786419.2019.1698571
Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation
Authors: Revie NM, Iyer KR, Maxson ME, Zhang J, Yan S, Fernandes CM, Meyer KJ, Chen X, Skulska I, Fogal M, Sanchez H, Hossain S, Li S, Yashiroda Y, Hirano H, Yoshida M, Osada H, Boone C, Shapiro RS, Andes DR, Wright GD, Nodwell JR, Del Poeta M, Burke MD, Whitesell L, Robbins N, Cowen LE.
Reference: Nat. Commun. Jun 2022; doi: 10.1080/14786419.2019.1698571
DNA damage-induced block of sporulation in Streptomyces venezuelae involves downregulation of ssgB
Authors: Falguera JVT, Stratton KJ, Bush MJ, Jani C, Findlay KC, Nodwell JR, Schlimpert S.
Reference: Microbiology (Reading). Jun 2022; doi: 10.1080/14786419.2019.1698571
2021
Metabolomic profiling and biological investigation of Tabebuia Aurea (Silva Manso) leaves, family Bignoniaceae
Authors: Mahmoud BK, Hamed ANE, Samy MN, Abdelmohsen UR, Attia EZ, Fawzy MA, Refaey RH, Salem MA, Pimentel-Elardo SM, Nodwell JR, Desoukey SY, Kamel MS.
Reference: Nat. Prod. Res. Nov 2021; doi: 10.1080/14786419.2019.1698571
A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase
Authors: MacAlpine J, Daniel-Ivad M, Liu Z, Yano J, Revie NM, Todd RT, Stogios PJ, Sanchez H, O’Meara TR, Tompkins TA, Savchenko A, Selmecki A, Veri AO, Andes DR, Fidel PL Jr, Robbins N, Nodwell JR, Whitesell L, Cowen LE.
Reference: Nat. Comm. Oct 2021; doi: 10.1038/s41467-021-26390-w
Biology and applications of co-produced, synergistic antimicrobials from environmental bacteria
Authors: Meyer KJ, Nodwell JR.
Reference: Nat. Microbiol. Sept 2021; doi: 10.1038/s41564-021-0095-6
The ARC2 response in Streptomyces coelicolor requires the global regulatory genes afsR and afsS
Authors: Calvelo VY, Crisante D, Elliot M, Nodwell JR.
Reference: Microbiology. May 2021; doi: 10.1099/mic.0.001047
A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa
Authors: Shah M, Taylor VL, Bona D, Tsao Y, Stanley SY, Pimentel-Elardo SM, McCallum M, Bondy-Demomy J, Howell PL, Nodwell JR, Davidson AR, Moraes TF, Maxwell KL.
Reference: Mol. Cell. Feb 2021; doi: 10.1016/j.molcel.2020.12.011
2020
An oxindole efflux inhibitor potentiates axoles and impairs virulence in the fungal pathogen Candida auris
Authors: Iyer KR, Camara K, Daniel-Ivad M, Trilles R, Pimentel-Elardo, SM, Fossen JL, Marchillo K, Liu Z, Singh S, Munoz JF, Kim SH, Porco JA Jr, Cuomo CA, Williams NS, Ibrahim AS, Edwards JE Jr, Andes DR, Nodwell JR, Brown LE, Whitesell L, Robbins N, Cowen LE.
Reference: Nat. Comm. Dec 2020; doi: 10.1038/s41467-020-20183-3
Chemical entrapment and killing of insects by bacteria
Authors: Ho LK, Daniel-Ivad M, Jeedigunta SP, Li J, Iliadi KG, Boulianne GL, Hurd TR, Smibert CA, Nodwell JR.
Reference: Nat. Comm. Sep 2020; doi: 10.1038/s41467-020-18462-0
Natural products repertoire of the Red Sea
Authors: El-Hossary EM, Abdel-Halim M, Ibrahim ES, Pimentel-Elardo SM, Nodwell JR, Handoussa H, Abdelwahab MF, Holzgrabe U, Abdelmohsen UR.
Reference: Mar. Drugs. Sep 2020; doi: 10.3390/md18090457
Dual-PKS cluster for biosynthesis of a light-induced secondary metabolite found from genome sequencing of Hyphodiscus hymeniophilus fungus
Authors: Kramer GJ, Pimentel-Elardo SM, Nodwell JR.
Reference: Chembiochem. Aug 2020; doi: 10.1002/cbic.201900689
Metabolomics analysis and biological investigation of three Malvaceae plants
Authors: Abdelhafez OH, Othman EM, Fahim JR, Desoukey SY, Pimentel-Elardo SM, Nodwell JR, Schirmeister T, Tawfike A, Abdelmohsen UR.
Reference: Phytochem Anal. Mar 2020; doi: 10.1002/pca.2883
2019
Discovery of a novel DNA gyrase-targeting antibiotic through chemical perturbation of Streptomyces venezuelae sporulation
Authors: McAuley S, Huynh A, Howells A, Walpole C, Maxwell A, Nodwell JR.
Reference: Cell Chem. Biol. Sep 2019; doi: 10.1016/j.chembiol.2019.06.002
Microbe Profile: Streptomyces coelicolor: a burlesque of pigments and phenotypes
Authors: Nodwell JR.
Reference: Microbiology. Sep 2019; doi: 10.1099/mic.0.000821
Put a bow on it: Knotted antibiotics take center stage
Authors: Tan S, Moore G, Nodwell JR.
Reference: Antibiotics. Aug 2019; doi: 10.3390/antibiotics8030117
Silencing cryptic specialized metabolism in Streptomyces by the nucleoid-associated protein Lsr2
Authors: Gehrke EJ, Zhang X, Pimentel-Elardo SM, Johnson AR, Rees CA, Jones SE, Hindra, Gehrke SS, Turvey S, Boursalie S, Hill JE, Carlson EE ,Nodwell JR, Elliot MA.
Reference: Elife. Jun 2019; doi: 10.7554/eLife.47691
The lasso peptide siamycin-I targets lipid II at the Gram-positive cell surface
Authors: Tan S, Ludwig KC, Muller A, Schneider T, Nodwell JR.
Reference: ACS Chem. Biol. May 2019; doi: 10.1021/acschembio.9b00157
A chemical inhibitor of cell growth reduces cell size in Bacillus subtilis
Authors: McAuley S, Vadia S, Jani C, Huynh A, Yang Z, Levin PA, Nodwell JR.
Reference: ACS Chem. Biol. Apr 2019; doi: 10.1021/acschembio.8b01066
2018
A chemical defence against phage infection
Authors: Kronheim S, Daniel-Ivad M, Duan Z, Hwang S, Wong AI, Mantel I, Nodwell JR, Maxwell KL.
Reference: Nature. Dec 2018; doi: 10.1038/s41586-018-0767-x
A new antitrypanosomal alkaloid from the Red Sea marine sponge Hyrtios sp.
Authors: Shady NH, Fouad MA, Ahmed S, Pimentel-Elardo SM, Nodwell JR, Kamel MS, Abdelmohsen UR.
Reference: J. Antibiot. Nov 2018; doi: 10.1038/s41429-018-0092-5
2017
Chromosome level assembly and secondary metabolite potential of the parasitic fungus Cordyceps militaris
Authors: Kramer GJ, Nodwell JR.
Reference: BMC Genomics. Nov 2017; doi: 10.1186/s12864-017-4307-0
Actinorhodin is a redox-active antibiotic with a complex mode of action against Gram-positive cells
Authors: Mak S, Nodwell JR.
Reference: Mol. Microbiol. Nov 2017; doi: 10.1111/mmi.13837
Antimicrobials: Expressing antibiotic gene clusters
Authors: Nodwell JR.
Reference: Nat. Microbiol. Apr 2017; doi: 10.1038/nmicrobiol.2017.61
An engineered allele of afsQ1 facilitates the discovery and investigation of cryptic natural products
Authors: Daniel-Ivad M, Hameed N, Tan S, Dhanjal R, Socko D, Pak P, Gverzdys T, Elliot MA, Nodwell JR.
Reference: ACS Chem. Biol. Mar 2017; doi: 10.1021/acschembio.6b01002
Streptomyces exploration is triggered by fungal interactions and volatile signals
Authors: Jones SE, Ho LK, Rees CA, Hill JE, Nodwell JR, Elliot MA.
Reference: Elife. Jan 2017; doi: 10.7554/eLife.21738
2016
Tetrodecamycin: An unusual and interesting tetronate antibiotic
Authors: Gverzdys T, Kramer GJ, Nodwell JR.
Reference: Bioorg. Med. Chem. Dec 2016; doi: 10.1016/j.bmc.2016.05.028
Biosynthetic genes for the tetrodecamycin antibiotics
Authors: Gverzdys T, Nodwell JR.
Reference: J. Bacteriol. Jun 2016; doi: 10.1128/JB.00140-16
David and Goliath: Chemical perturbation of eukaryotes by bacteria
Authors: Ho LK, Nodwell JR.
Reference: J. Ind. Microbiol. Biotechnol. Mar 2016; doi: 10.1007/s10295-015-1686-6
2015
Activity-independent discovery of secondary metabolites using chemical elicitation and chemoinformatic inference
Authors: Pimentel-Elardo SM, Sorensen D, Ho LK, Ziko M, Bueler SA, Lu S, Tao K, Moser A, Lee R, Agard D, Fairn G, Rubinstein JL, Shoichet BK, Nodwell JR.
Reference: ACS Chem. Biol. Nov 2015; doi: 10.1021/acschembio.5b00612
13-deoxytetrodecamycin, a new tetronate ring-containing antibiotic that is active against multidrug-resistant Staphylococcus aureus
Authors: Gverzdys T, Hart MK, Pimentel-Elardo SM, Tranmer G, Nodwell JR.
Reference: J. Antibiot. Nov 2015; doi: 10.1038/ja.2015.60
Streptomyces: a screening tool for bacterial cell division inhibitors
Authors: Jani C, Tocheva EI, McAuley S, Craney A, Jensen GJ, Nodwell JR.
Reference: J. Biomol. Screen. Feb 2015; doi: 10.1177/1087057114551334